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Titanium Nitride Thin Film Formation on Metal Substrate by Chemical Vapor Deposition in a Magnetized Sheet Plasma Source

Through the advanced technology developed by Dr. Ramos and his research team, it is now possible to enhance the lifetime of tools through coating. A magnetized sheet plasma source provides a wear-resistant titanium nitride (TiN) tool coating at less than a quarter of the cost of carbide coating and similar techniques. The coating process is superior to other techniques because it is relatively fast and does not require very high temperatures that could damage the material being coated.

Applications: cutting tools manufacturing industry, aerospace components, automotive parts, broaches, decorative accessories, dental instruments, door hardware, eyeglass frames, firearms components, food processing equipment, hobs, jewelry, marine hardware, medical devices, pharmaceutical equipment, plastic molds, plumbing fixtures, precision gears, sporting goods, surgical implants and writing instruments

Patent Application Status: Taiwan Patent granted 16 March 2007; Philippines, Europe, Japan, People’s Republic of China, Singapore, US, Malaysian, and PCT Patents Pending

Date of Filing:

  • Taiwan Patent (Application No.: 91132002): 28 October 2002
  • Philippine Patent (Application No.: 1-2004-502138): 27 August 2004
  • Europe Patent (Application No.: 02807011.8-2119): 9 September 2004
  • Japan Patent (Application No.: 2003-573196): 23 August 2004
  • People’s Republic of China Patent (Application No.: 2828340.6): 10 September 2004
  • Singapore Patent (Application No.: 200404858-3): 27 February 2004
  • US Patent (Application No.: 10/505.794): 27 August 2004
  • Malaysia Patent (Application No.: PI 20024041): 29 October 2002
  • PCT Patent (Application No.: PCT/PH02/0003): 27 February 2002

About the Inventor:

  • Henry J. RamosCurrent Position: Professor of Physics, National Institute of Physics, UP Diliman, Quezon City
    Research interests: negative ion sources for the production of high grade films (e.g. TiN, ZrN, TiCN) and ion plating, plasma-enhanced chemical vapor deposition for the formation of diamond and diamond-like carbon (DLC) thin films ion source development and plasma chemistry applications, beam transport and plasma dynamics, sterilization using plasmas, ion irradiation of polymers

    Most recent Scientific Contributions/Publications:

    • Titanium Nitride Thin Film Formation on Metal Substrate by Chemical Vapor Deposition in a Magnetized Sheet Plasma Source (Taiwan patent granted)
    • G.Q. Blantocas, P.E.R. Mateum, R.W.M. Orille, R.J.U. Ramos, J.L.C. Monasterial, H.J. Ramos, L.M.T. Bo-ot, “Inhibited flammability and surface inactivation of wood irradiated by low energy hydrogen ion showers (LEHIS),” Nuclear Instrum. Methods B 259 (2007) 875-883.

Synergistic combination of marine compounds and use thereof in the treatment of cancer

Two cytotoxic marine natural products, heptyl prodigiosin and adociaquinone B, each with significant cytotoxicity to human cancer cell lines and with a different mechanism of action, were combined in different proportions. These combinations were shown to be synergistic or more cytotoxic to the human cancer cell lines than when each compound was applied individually.

Patent Application Status: Philippine Patent Pending
Date of Filing: 3 September 2004
Application No.: 1-2004-00379

About the Inventor:

  • Gisela P. Concepcion

    Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
    Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods

Process for the preparation of mitoxantrone

The out-of-patent anticancer drug mitoxantrone was chemically synthesized via a different synthetic route from that published in the literature. The synthesis was achieved and optimized in a Philippine setting, considering the availability of reagents and the limitation of experimental setups for chemical synthesis. Mitoxantrone has the same efficacy as the standard, widely used anticancer drug doxorubicin, except that mitoxantrone exhibits no or less cardiac toxicity, because unlike doxorubicin, it is not a glycoside.

Patent Application Status: Philippine Patent Pending
Date of Filing: 3 November 2004
Application No.: 1-2004-00490

About the Inventors:

  • Gisela P. Concepcion

    Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
    Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods

  • Lourdes J. Cruz

    Current Position: Professor, Marine Science Institute, UP Diliman Q.C.
    Research Interests: Conopeptides and other neuroactive compounds, paralytic shellfish poisons and other marine toxins, screening for anti-TB compounds, biodiversity and drug development

    Most Recent Scientific Contributions/Publications:

    • Imperial JS, Watkins M. Chen P, Hillyard DR, Cruz LJ, Olivera BM. 2003. The augertoxins: biochemical characterization of venom components from the toxoglossate gastropod Terebra subulata. 42:391-8.
    • Jimenez EC, Shetty RP, Lirazan M. Rivier J, Walker C, Abogadie FC, Yoshikama D, Cruz LJ, Olivera BM. 2003. Novel excitatory Conus peptides define a new conotoxin superfamily. J. Neurochem. 85:610-21.
    • Espiritu, J. D., Cruz, L. J., Cartier, G. E. and Oliver, B. M. (2002). Venomous Gastropods: Conus, conoideans and other neogastropod families. Supplement 4, Systematics, Phylogeny and Biology of the Neogastropoda, 3rd International Workshop on Malacology. Bolletino Malacologico 38: 147-160.

Microorganism and the use thereof for producing heptylprodigiosin and the use of heptylprodigiosin

A marine microorganism isolated from a marine sponge collected in the Philippines produces the compound hetylprodigiosin in significant quantity when cultured in the laboratory. The microorganism was characterized and identified to be novel. Heptyl prodigiosin exhibits antimicrobial and cytotoxic properties.

Patent Application Status: Philippine Patent Pending
Application No.: 1-2002-000516

About the Inventor:

  • Gisela P. Concepcion

    Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
    Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods

Method for Generating High-Contrast Images of Semiconductor Sites via One-photon Optical Beam-Induced Current Imaging and Confocal Reflectance Microscopy

Dr. Saloma and his team developed a microscopic imaging technique that effectively discriminates between semiconductor and metal materials in an integrated circuit. This was done by utilizing one-photon optical beam-induced current (1P-OBIC) and confocal reflectance images, which are both generated using the same excitation laser beam. Compared to the two-photon optical beam-induced current imaging that also generates high-contrast images of semiconductor sites, the hardware support for this 1P-OBIC procedure is significantly cheaper. Using this principle in a combined OBIC and confocal microscope system allows for effective visualization of semiconductor integrated circuits, which is useful for failure analysis and other applications.

Applications: semiconductor industry, academic research insititutes

Patent Application Status: US Patent granted 26 June 2007; Philippines and PCT Patents Pending

Date of Filing:

  • US Patent (Application No.: 10/520.729): 7 January 2005
  • Philippine Patent (Application No.: 1-2005-50056): 7 January 2005
  • PCT Patent (Application No.: PCT/PH02/00013): 9 July 2002

About the Inventors:

  • Caesar S. Saloma

    Current Position: Dean, College of Science, UP Diliman, Quezon City
    Research interests: Photonics, Optics, Optical Microscopy and Spectroscopy

    Most recent Scientific Contributions/Publications:

    • Method for Generating High-Contrast Images of Semiconductor Sites via One-photon Optical Beam-Induced Current Imaging and Confocal Reflectance Microscopy (US patent granted)
    • Two Color (Two Photon) Excitation with Focused Excitation Beams and a Raman Shifter
    • W. Oblefias, M. Soriano, A Tarun and C Saloma, “Individual Classification of buried transistors in live microprocessors by functional infrared emission spectral microscopy,” Appl Phys Lett 89, 151113 (2006)
    • Vincent Daria

      Current Position: Associate Professor, National Institute of Physics, UP Diliman, Quezon City

      Research interests: Wavefront Engineering, Programmable phase optics, Micro-fabrication, Non-linear optical processes, optical trapping, High performance computing, numerical coding

      Most recent Scientific Contributions/Publications:

      • Method for Generating High-Contrast Images of Semiconductor Sites via One-photon Optical Beam-Induced Current Imaging and Confocal Reflectance Microscopy
      • D Palima and VR Daria, “Effect of Spurious diffraction orders in arbitrary multi-foci patterns produced via phase-only holograms,” Appl Opt 45, 6689-6693 (2006)
    • Jelda Jane Miranda

      Current Position:

      Research interests: Optics, microscopy, semiconductor failure analysis, IO/parametric test

      Most recent Scientific Contributions/Publications:

      • Method for Generating High-Contrast Images of Semiconductor Sites via One-photon Optical Beam-Induced Current Imaging and Confocal Reflectance Microscopy
      • JJ Miranda and C Saloma, “Four-Dimensional microscopy of defects integrated circuits,” Appl Opt 42, (2003)

    Method for detecting TAG-72 using CC92 and CC49 monoclonal antibodies and use thereof for cancer diagnosis, prognosis and monitoring

    A prototype cancer immunodiagnostic kit was developed which detects the presence of the pancarcinomic tumor antigen TAG-72 in serum. This ELISA sandwich method makes use of the monoclonal antibodies against TAG-72, namely: CC92 as capture antibody and CC49 as detecting antibody. When TAG-72 levels are measured in parallel with CEA levels (standard cancer diagnostic), monitoring and prognosis of cancer patients can be improved.

    Patent Application Status: Philippine Patent Pending

    Date of Filing: 12 July 2004
    Application No.: 1-2004-00285

    About the Inventor:

    • Gisela P. Concepcion

      Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
      Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods

    In vivo method for selecting antibodies, their derivatives and antibody-mediated therapies against breast cancer

    A mouse tumor model was developed that allows the preliminary testing of candidate therapeutic antibodies and antibody conjugates targeted to the human pancarcinomic tumor antigen TAG-72. A mouse tumor antigen, expressed on the surface of mouse mammary tumors growing in mice, is detected by the TAG-72 monoclonal antibody CC49 by immunohistochemistry. The mammary tumor in mice regresses when intravenously injected with CC49 or a CC49-drug conjugate.

    About the Inventor:

    • Gisela P. Concepcion

      Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
      Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods

    Cyclic hexapeptides, process and use thereof

    Two novel cyclic hexapeptides, microcionamides A and B, which are geometric isomers, were isolated from a sponge collected in the Philippines. These compounds exhibit significant cytotoxicity and induce apoptosis (programmed cell death in human cancer cell lines.

    About the Inventor:

    • Gisela P. Concepcion

      Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
      Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods

    Salivary IgA E. histolytica Detection Kit

    Dr. Rivera and his team developed a fast, accurate and convenient detection kit for Entamoeba histolytica, the pathogen that causes amebiasis. The Salivary IgA E. histolytica detection kit is more accurate and less time-consuming than traditional methods of identifying E. histolytica such as microscopy. The kit is self-contained and results can be read without the use of specialized instruments. The kit uses salivary samples, which are more convenient to obtain from patients, as opposed to stool samples which are used by traditional E. histolytica detection methods.

    About the Inventor:

    • Windell Rivera

    Current position: Associate Professor Institute of Biology, College of Science, UP Diliman Q.C.
    Research Interests: Molecular Biology and Immunology, Medical Biotechnology, and Molecular Diagnostics and Epidemiology

    • Angeline Odelia Concepcion
    • Alexander Edward Dy

    UP in Alibata Characters & Device

    Description of the Mark:

    The mark consists of a rectangular-shaped band of cloth tapered at the top and flowing at the bottom.  In the middle of the device is a column with a design of a flower followed by the Alibata character for “U” and the Alibata character for “P”.  On both sides of the column containing the letters and flowers is a column of diamond shaped figures bordered by a zigzag line and straight line thereafter.  On the left side of the left diamond column is a wide column followed by a narrow column and a wide column thereafter.  On the right side of the right diamond column is a wide column followed by a narrow column and a wide column thereafter.

    Manner of Using the Mark:

    By means of displaying in academic costumes, signages at its offices, in business cards, stationeries, magazines, contracts, brochures, announcements, pamphlets, displays and other materials published or used in connection with the services, or in any manner customary to the trade.

    Registration No.: 4-2002-0010939
    Date of Registration: 01 October 2005
    Date of Issuance of Certificate of Registration: 26 April 2006

    About the Creators:

    • Virginia D. Monje is a Professor at the National Institute of Molecular Biology and Biotechnology of the College of Science.
    • Rogelio L. Juliano Jr. (deceased) is a former Associate Professor at the Department of Speech Communications and Theater Arts of the College of Arts and Letters.
    • Abraham P. Sakili is an Associate Professor at the Department of Art Studies of the College of Arts and Letters.
    • Antoinette B. Hernandez is an Associate Professor at the Department of Speech Communications and Theater Arts of the College of Arts and Letters.
    • Consuelo J. Paz is a retired Professor at the College of Social Sciences and Philosophy.
    • Carmen G. Diaz de Ventanilla is a retired Professor at the University of the Philippines.
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