In vivo method for selecting antibodies, their derivatives and antibody-mediated therapies against breast cancer
A mouse tumor model was developed that allows the preliminary testing of candidate therapeutic antibodies and antibody conjugates targeted to the human pancarcinomic tumor antigen TAG-72. A mouse tumor antigen, expressed on the surface of mouse mammary tumors growing in mice, is detected by the TAG-72 monoclonal antibody CC49 by immunohistochemistry. The mammary tumor in mice regresses when intravenously injected with CC49 or a CC49-drug conjugate.
About the Inventor:
- Gisela P. Concepcion
Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods
and 
, originating from the indigenous alphabet called baybayin or katitikan, are equivalent to the Roman letters “U” and “P”, respectively. The curvilinear design called ukkil or ukit, which resembles a sprouting plant, signifies life. The geometric designs (in zigzag and diamond patterns) are common design elements gracing the attires and functional objects of indigenous peoples from Batanes to Tawi-tawi. Arranged continuously and rhythmically, these geometric designs highlight the diverse cultural communities in the Philippines and the University’s pursuit of knowledge, cultural enrichment, and scientific advancement.
