Featured Technologies for Licensing
| Patents | Utility Models |
Patents
- Salivary IgA E. histolytica Detection Kit
Inventor: Windell L. Rivera, Angeline Odelia C. Concepcion, Alexander Edward S. Dy - Cyclic hexapeptides, process and use thereof
Inventor: Gisela P. Concepcion - In vivo method for selecting antibodies, their derivatives and antibody-mediated therapies against breast cancer
Inventor: Gisela P. Concepcion - Method for detecting TAG-72 using CC92 and CC49 monoclonal antibodies and use thereof for cancer diagnosis, prognosis and monitoring
Inventor: Gisela P. Concepcion - Method for Generating High-Contrast Images of Semiconductor Sites via One-photon Optical Beam-Induced Current Imaging and Confocal Reflectance Microscopy
Inventors: Ceasar S. Saloma, Vincent Daria, Jelda Jane Miranda - Microorganism and the use thereof for producing heptylprodigiosin and the use of heptylprodigiosin
Inventor: Gisela P. Concepcion - Process for the preparation of mitoxantrone
Inventor: Gisela P. Concepcion - Synergistic combination of marine compounds and use thereof in the treatment of cancer
Inventor: Gisela P. Concepcion - Titanium Nitride Thin Film Formation on Metal Substrate by Chemical Vapor Deposition in a Magnetized Sheet Plasma Source
Inventor: Henry J. Ramos - Two Color (Two Photon) Excitation with Focused Excitation Beams and a Raman Shifter
Inventors: Ceasar A. Saloma, Wilson O. Garcia, Jonathan Palero
Utility Models
- Seaweed-Based Air Freshener Gel
Inventors: Marco Nemesio E. Montaño, Banaag Glorioso-Lajera - Time Keeping Device
Inventors: Prof. Michael Angelo Pedrasa, Prof. Jhoanne Rhodette A. Ibabao, Prof. Joy Alinda P. Reyes, Prof. Emerson C. Tan
Patents
- Salivary IgA E. histolytica Detection Kit
Dr. Rivera and his team developed a fast, accurate and convenient detection kit for Entamoeba histolytica, the pathogen that causes amebiasis. The Salivary IgA E. histolytica detection kit is more accurate and less time-consuming than traditional methods of identifying E. histolytica such as microscopy. The kit is self-contained and results can be read without the use of specialized instruments. The kit uses salivary samples, which are more convenient to obtain from patients, as opposed to stool samples which are used by traditional E.histolytica detection menthods.
About the Inventor:
- Windell Rivera
Current position: Associate Professor Institute of Biology, College of Science, UP Diliman Q.C.
Research Interests: Molecular Biology and Immunology, Medical Biotechnology, and Molecular Diagnostics and Epidemiology
- Angeline Odelia Concepcion
- Alexander Edward Dy
- Cyclic hexapeptides, process and use thereof
Two novel cyclic hexapeptides, microcionamides A and B, which are geometric isomers, were isolated from a sponge collected in the Philippines. These compounds exhibit significant cytotoxicity and induce apoptosis (programmed cell death in human cancer cell lines.
About the Inventor:
- Gisela P. Concepcion
Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods
- In vivo method for selecting antibodies, their derivatives and antibody-mediated therapies against breast cancer
A mouse tumor model was developed that allows the preliminary testing of candidate therapeutic antibodies and antibody conjugates targeted to the human pancarcinomic tumor antigen TAG-72. A mouse tumor antigen, expressed on the surface of mouse mammary tumors growing in mice, is detected by the TAG-72 monoclonal antibody CC49 by immunohistochemistry. The mammary tumor in mice regresses when intravenously injected with CC49 or a CC49-drug conjugate.
About the Inventor:
- Gisela P. Concepcion
Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods
- Method for detecting TAG-72 using CC92 and CC49 monoclonal antibodies and use thereof for cancer diagnosis, prognosis and monitoring
A prototype cancer immunodiagnostic kit was developed which detects the presence of the pancarcinomic tumor antigen TAG-72 in serum. This ELISA sandwich method makes use of the monoclonal antibodies against TAG-72, namely: CC92 as capture antibody and CC49 as detecting antibody. When TAG-72 levels are measured in parallel with CEA levels (standard cancer diagnostic), monitoring and prognosis of cancer patients can be improved.
Patent Application Status: Philippine Patent Pending
Date of Filing: 12 July 2004
Application No.: 1-2004-00285
About the Inventor:
- Gisela P. Concepcion
Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods
- Method for Generating High-Contrast Images of Semiconductor Sites via One-photon Optical Beam-Induced Current Imaging and Confocal Reflectance MicroscopyDr. Saloma and his team developed a microscopic imaging technique that effectively discriminates between semiconductor and metal materials in an integrated circuit. This was done by utilizing one-photon optical beam-induced current (1P-OBIC) and confocal reflectance images, which are both generated using the same excitation laser beam. Compared to the two-photon optical beam-induced current imaging that also generates high-contrast images of semiconductor sites, the hardware support for this 1P-OBIC procedure is significantly cheaper. Using this principle in a combined OBIC and confocal microscope system allows for effective visualization of semiconductor integrated circuits, which is useful for failure analysis and other applications.
Applications: semiconductor industry, academic research insititutes
Patent Application Status: US Patent granted 26 June 2007; Philippines and PCT Patents Pending
Date of Filing: - US Patent (Application No.: 10/520.729): 7 January 2005
- Philippine Patent (Application No.: 1-2005-50056): 7 January 2005
- PCT Patent (Application No.: PCT/PH02/00013): 9 July 2002
About the Inventors:
- Caesar S. Saloma
Current Position: Dean, College of Science, UP Diliman, Quezon City
Research interests: Photonics, Optics, Optical Microscopy and Spectroscopy
Most recent Scientific Contributions/Publications: - Method for Generating High-Contrast Images of Semiconductor Sites via One-photon Optical Beam-Induced Current Imaging and Confocal Reflectance Microscopy (US patent granted)
- Two Color (Two Photon) Excitation with Focused Excitation Beams and a Raman Shifter
- W. Oblefias, M. Soriano, A Tarun and C Saloma, “Individual Classification of buried transistors in live microprocessors by functional infrared emission spectral microscopy,” Appl Phys Lett 89, 151113 (2006)
- Vincent Daria
Current Position: Associate Professor, National Institute of Physics, UP Diliman, Quezon City
Research interests: Wavefront Engineering, Programmable phase optics, Micro-fabrication, Non-linear optical processes, optical trapping, High performance computing, numerical coding
Most recent Scientific Contributions/Publications: - Method for Generating High-Contrast Images of Semiconductor Sites via One-photon Optical Beam-Induced Current Imaging and Confocal Reflectance Microscopy
- D Palima and VR Daria, “Effect of Spurious diffraction orders in arbitrary multi-foci patterns produced via phase-only holograms,” Appl Opt 45, 6689-6693 (2006)
- Jelda Jane Miranda
Current Position:
Research interests: Optics, microscopy, semiconductor failure analysis, IO/parametric test
Most recent Scientific Contributions/Publications: - Method for Generating High-Contrast Images of Semiconductor Sites via One-photon Optical Beam-Induced Current Imaging and Confocal Reflectance Microscopy
- JJ Miranda and C Saloma, “Four-Dimensional microscopy of defects integrated circuits,” Appl Opt 42, (2003)
- Microorganism and the use thereof for producing heptylprodigiosin and the use of heptylprodigiosin
A marine microorganism isolated from a marine sponge collected in the Philippines produces the compound hetylprodigiosin in significant quantity when cultured in the laboratory. The microorganism was characterized and identified to be novel. Heptyl prodigiosin exhibits antimicrobial and cytotoxic properties.
Patent Application Status: Philippine Patent Pending
Application No.: 1-2002-000516
About the Inventor:
- Gisela P. Concepcion
Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods
- Process for the preparation of mitoxantrone
The out-of-patent anticancer drug mitoxantrone was chemically synthesized via a different synthetic route from that published in the literature. The synthesis was achieved and optimized in a Philippine setting, considering the availability of reagents and the limitation of experimental setups for chemical synthesis. Mitoxantrone has the same efficacy as the standard, widely used anticancer drug doxorubicin, except that mitoxantrone exhibits no or less cardiac toxicity, because unlike doxorubicin, it is not a glycoside.
Patent Application Status: Philippine Patent Pending
Date of Filing: 3 November 2004
Application No.: 1-2004-00490
About the Inventors:
- Gisela P. Concepcion
Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods - Lourdes J. Cruz
Current Position: Professor, Marine Science Institute, UP Diliman Q.C.
Research Interests: Conopeptides and other neuroactive compounds, paralytic shellfish poisons and other marine toxins, screening for anti-TB compounds, biodiversity and drug development
Most Recent Scientific Contributions/Publications: - Imperial JS, Watkins M. Chen P, Hillyard DR, Cruz LJ, Olivera BM. 2003. The augertoxins: biochemical characterization of venom components from the toxoglossate gastropod Terebra subulata. 42:391-8.
- Jimenez EC, Shetty RP, Lirazan M. Rivier J, Walker C, Abogadie FC, Yoshikama D, Cruz LJ, Olivera BM. 2003. Novel excitatory Conus peptides define a new conotoxin superfamily. J. Neurochem. 85:610-21.
- Espiritu, J. D., Cruz, L. J., Cartier, G. E. and Oliver, B. M. (2002). Venomous Gastropods: Conus, conoideans and other neogastropod families. Supplement 4, Systematics, Phylogeny and Biology of the Neogastropoda, 3rd International Workshop on Malacology. Bolletino Malacologico 38: 147-160.
- Synergistic combination of marine compounds and use thereof in the treatment of cancer
Two cytotoxic marine natural products, heptyl prodigiosin and adociaquinone B, each with significant cytotoxicity to human cancer cell lines and with a different mechanism of action, were combined in different proportions. These combinations were shown to be synergistic or more cytotoxic to the human cancer cell lines than when each compound was applied individually.
Patent Application Status: Philippine Patent Pending
Date of Filing: 3 September 2004
Application No.: 1-2004-00379
About the Inventor:
- Gisela P. Concepcion
Current Position: Associate Professor, Marine Science Institute, UP Diliman Q.C.
Research Interests: Marine Natural Products, Biochemistry, Development of Bioscreening Methods
- Titanium Nitride Thin Film Formation on Metal Substrate by Chemical Vapor Deposition in a Magnetized Sheet Plasma Source
Through the advanced technology developed by Dr. Ramos and his research team, it is now possible to enhance the lifetime of tools through coating. A magnetized sheet plasma source provides a wear-resistant titanium nitride (TiN) tool coating at less than a quarter of the cost of carbide coating and similar techniques. The coating process is superior to other techniques because it is relatively fast and does not require very high temperatures that could damage the material being coated.
Applications: cutting tools manufacturing industry, aerospace components, automotive parts, broaches, decorative accessories, dental instruments, door hardware, eyeglass frames, firearms components, food processing equipment, hobs, jewelry, marine hardware, medical devices, pharmaceutical equipment, plastic molds, plumbing fixtures, precision gears, sporting goods, surgical implants and writing instruments
Patent Application Status: Taiwan Patent granted 16 March 2007; Philippines, Europe, Japan, People’s Republic of China, Singapore, US, Malaysian, and PCT Patents Pending
Date of Filing:
- Taiwan Patent (Application No.: 91132002): 28 October 2002
- Philippine Patent (Application No.: 1-2004-502138): 27 August 2004
- Europe Patent (Application No.: 02807011.8-2119): 9 September 2004
- Japan Patent (Application No.: 2003-573196): 23 August 2004
- People’s Republic of China Patent (Application No.: 2828340.6): 10 September 2004
- Singapore Patent (Application No.: 200404858-3): 27 February 2004
- US Patent (Application No.: 10/505.794): 27 August 2004
- Malaysia Patent (Application No.: PI 20024041): 29 October 2002
- PCT Patent (Application No.: PCT/PH02/0003): 27 February 2002
About the Inventor:
- Henry J. Ramos
Current Position: Professor of Physics, National Institute of Physics, UP Diliman, Quezon City
Research interests: negative ion sources for the production of high grade films (e.g. TiN, ZrN, TiCN) and ion plating, plasma-enhanced chemical vapor deposition for the formation of diamond and diamond-like carbon (DLC) thin films ion source development and plasma chemistry applications, beam transport and plasma dynamics, sterilization using plasmas, ion irradiation of polymers
Most recent Scientific Contributions/Publications: - Titanium Nitride Thin Film Formation on Metal Substrate by Chemical Vapor Deposition in a Magnetized Sheet Plasma Source (Taiwan patent granted)
- G.Q. Blantocas, P.E.R. Mateum, R.W.M. Orille, R.J.U. Ramos, J.L.C. Monasterial, H.J. Ramos, L.M.T. Bo-ot, “Inhibited flammability and surface inactivation of wood irradiated by low energy hydrogen ion showers (LEHIS),” Nuclear Instrum. Methods B 259 (2007) 875-883.
- Two Color (Two Photon) Excitation with Focused Excitation Beams and a Raman Shifter
Dr. Saloma and his team have invented a method for inducing highly localized light absorption in materials via two-color (two-photon) excitation (2CE). Compared to conventional methods, including two-photon single color excitation, two-color fluorescence excitation results in a higher spatial resolution. Furthermore, it is robust against effects of two-beam interference and breakdowns in confocality of the focused excitation beams. This technique can be applied to two-color fluorescence microscopy of optically thick and irregularly shaped biological samples.
Optical beam-induced current imaging is a failure analysis technique for determining the presence of defects and discontinuities in an integrated circuit. The advantages of two-color excitation can be extended to it for the enhancement of resolution and image contrast. This technology is a key component of a practical 2CE microscope.
Applications: biomedical imaging, failure analysis in semiconductor industry
Patent Application Status: Philippines, US, and PCT Patents Pending
Date of Filing:
- Philippine Patent (Application No.: 1-2005-500584): 22 March 2004
- US Patent (Application No.: 10/529.043): 22 March 2004
- PCT Patent (Application No.: PCT/PH02/00018): 27 September 2002
About the Inventors:
- Ceasar A. Saloma
Current Position: Dean, College of Science, UP Diliman, Quezon City
Research interests: Photonics, Optics, Optical Microscopy and Spectroscopy
Most recent Scientific Contributions/Publications: - Method for Generating High-Contrast Images of Semiconductor Sites via One-photon Optical Beam-Induced Current Imaging and Confocal Reflectance Microscopy (US patent granted)
- Two Color (Two Photon) Excitation with Focused Excitation Beams and a Raman Shifter
- W. Oblefias, M. Soriano, A Tarun and C Saloma, “Individual Classification of buried transistors in live microprocessors by functional infrared emission spectral microscopy,” Appl Phys Lett 89, 151113 (2006)
- Wilson O. Garcia
Current Position: Associate Professor, National Institute of Physics, UP Diliman, Q.C.
Research interests: Lasers, Optics and Spectroscopy
Most recent Scientific Contributions/Publications: - C. Alonzo, W. Garcia and C. Saloma, “Generation of Optical Beam-Induced Current via Two-Color (Two-Photon) Excitation Optics Communications 246, 117-122 (2005)
- Two Color (Two Photon) Excitation with Focused Excitation Beams and a Raman Shifter
- Jonathan Palero
Utility Models
- Seaweed-Based Air Freshener Gel
Dr. Montaño and his team developed a seaweed-based air freshener with a characteristic gel-like texture. The low-cost air freshener makes use of the whole seaweed instead of the extracted polysaccharide leading to lower production cost. The base allows a slow release of the essence thus prolonging its shelf life. Unlike the fresheners commercially available, the seaweed-based air freshener can be divided into shapes and sizes for easier packing and utilization.
Applications: deodorant manufacturing, home care sector, environmental health care
Utility Model Application Status: Utility Model Registration Certificate Issued 9 March 2007
Date of Filing: 30 January 1996
Utility Model Registration Certificate No.: 2-1996-15501
About the Inventors:
- Marco Nemesio E. Montaño
Current Position: Professor, Marine Science Institute, UP Diliman, Q.C.
Research interests: Marine Chemistry, natural products from marine organisms and seaweed chemistry and utilization - Banaag Glorioso-Lajera
Current Position: A former Research Associate of Dr. Montaño and is currently the head of Seaweed Processing at CP Kelco Inc. in Cebu City.
- Time Keeping Device
This system integrates a barcode reader, fingerprint sensor and Transmission Control Protocol/Internet Protocol (TCP/IP) connectivity, allowing for remote employee log-in over a WAN/LAN and user verification through off-line fingerprint matching. This system enables unlimited number of terminals to connect to a single centralized server, eliminating the need for dedicated personal computers to be connected to each terminal. This utility model addresses the issue of user verification by collecting log-in information containing barcode data and fingerpring image for biometric identification.
Applications: industry personnel log-in information, employee attendance verification, personnel biometric identification
Utility Model Application Status: Utility Model Registration Certificate issued 11 December 2006
Date of Filing: 8 May 2003
Utility Model Registration Certificate No.: 2-2003-000176
About the Inventors:
- Michael Angelo Pedrasa
- Jhoanne Rhodette A. Ibabao
Current Position: Assistant Professor I, Department of Electrical and Electronics Engineering, UP Diliman, Q. C.
Research interests: Computer Networks, TCP/IP, Quality of Service, Scheduling Mechanisms, Jitter management
Most recent Scientific Contributions/Publications: - Time Keeping Device
- “Diliman Network Simulation” (paper presented at the 4th National ECE Conference, San Carlos University Cebu City, November 2003)
- Joy Alinda P. Reyes
Current Position: Assistant Professor, Department of Electrical and Electronics Engineering, UP Diliman, Quezon City
Research interests: Digital VLSI Design; Computer Architecture; Microelectronics
Most recent Scientific Contributions/Publications: - Time Keeping Device
- A Study of Floating-Point Architectures for Pipelined RISC Processors (Masters thesis)
- Emerson C. Tan